Article
Sib pair linkage analysis of renin gene haplotypes in human essential hypertension.
Human genetics - 1 Jan 1992
Jeunemaitre X, Rigat B, Charru A, Houot A M, Soubrier F, Corvol P
Abstract excerpt
Although essential arterial hypertension is believed to have a strong genetic predisposition, the gene(s) responsible are unknown. The mechanisms underlying the regulation of blood pressure and experimental studies place the renin gene among the main candidate genes that need to be tested in humans. We tested the hypothesis of a linkage between the renin gene and essential hypertension using the affected sib pair...
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