Article
Evaluation of the angiotensinogen locus in human essential hypertension: a European study.
Hypertension (Dallas, Tex. : 1979) - 1 Mar 1998
Brand E, Chatelain N, Keavney B, Caulfield M, Citterio L, Connell J, Grobbee D, Schmidt S, Schunkert H, Schuster H, Sharma A M, Soubrier F
Abstract excerpt
Different family and case-control studies support genetic linkage and association at the human angiotensinogen (AGT) locus with essential hypertension. To extend these previous observations, a European collaborative study of nine centers was set up to create a large resource of affected sibling pairs. The AGT locus was studied using a highly polymorphic dinucleotide repeat in the 3'-flanking region of the gene in...
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