Article
Association between an alpha(2) macroglobulin DNA polymorphism and late-onset Alzheimer's disease.
Biochemical and biophysical research communications - 14 Oct 1999
Alvarez V, Alvarez R, Lahoz C H, Martínez C, Peña J, Guisasola L M, Salas-Puig J, Morís G, Uría D, Menes B B, Ribacoba R, Vidal J A, Sánchez J M, Coto E
Abstract excerpt
An association between a five-base-pair deletion/insertion DNA polymorphism at the alpha(2) macroglobulin gene (A2M) and late-onset Alzheimer's disease (LOAD) has been recently described. We developed a PCR assay to analyze this polymorphism in 190 LOAD patients (older than 65 years) and 400 controls from Spain. Controls were stratified into three groups: <65 years (n = 200), 65 to 80 years (n = 100), and 81...
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