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Article

Gene conversion events contribute to the polymorphic variation of the surrogate light chain gene lambda 5/14.1.

Clinical immunology (Orlando, Fla.) - 1 Nov 1999

Conley M E, Rapalus L, Boylin E C, Rohrer J, Minegishi Y

Abstract excerpt

Normally occurring and experimentally induced models of immunodeficiency indicate that B cell development and antibody production are influenced by genetic factors. It is highly likely that polymorphic variants in genes that encode receptors for growth and differentiation factors, signal transduction molecules, and components of the B cell and pre-B-cell receptor complex contribute to this genetic control. We...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 10527692
DOI: 10.1006/clim.1999.4785

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Gene conversion events contribute to the polymorphic variation of the surrogate light chain gene lambda 5/14.1.PMID 10527692Read ↗

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The pre-B-cell receptor induces silencing of VpreB and lambda5 transcription.Semantic proximity Read ↗

The unique and immunoglobulin-like regions of surrogate light chain component lambda5 differentially interrogate immunoglobulin heavy-chain structure.Semantic proximity Read ↗

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