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Article

B-cell development: a comparison between mouse and man.

Immunology today - 1 Oct 1998

Ghia P, ten Boekel E, Rolink A G, Melchers F

Abstract excerpt

A common variable immunodeficiency (CVID) patient, who carries mutations on both alleles of the gene encoding the surrogate light chain component lambda 5/14.1, shows a similar phenotype of B-cell deficiency as the lambda 5-deficient mutant mouse. As discussed here by Paolo Ghia and colleagues, this points to a remarkably similar developmental pathway of B cells in humans and mice.

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Identifiers

PMID: 9785673
DOI: 10.1016/s0167-5699(98)01330-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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