Article
B-cell development: a comparison between mouse and man.
Immunology today - 1 Oct 1998
Ghia P, ten Boekel E, Rolink A G, Melchers F
Abstract excerpt
A common variable immunodeficiency (CVID) patient, who carries mutations on both alleles of the gene encoding the surrogate light chain component lambda 5/14.1, shows a similar phenotype of B-cell deficiency as the lambda 5-deficient mutant mouse. As discussed here by Paolo Ghia and colleagues, t...
Topics
- Age Factors
- Animals
- B-Lymphocytes
- Cell Differentiation
- Chick Embryo
- Common Variable Immunodeficiency
- Gene Rearrangement, B-Lymphocyte, Light Chain
- Humans
- Mice
- Phenotype