Article
Monoallelic expression of reactivated imprinted genes in embryonal carcinoma cell hybrids.
Experimental cell research - 1 Nov 1999
Forejt J, Saam J R, Gregorová S, Tilghman S M
Abstract excerpt
Though DNA methylation is necessary to maintain monoallelic expression of imprinted genes, it is still unclear whether it represents the primary mark. Here we ask whether the imprinting mark is still present in terminally differentiated somatic cells in which the transcription of embryo-specific imprinted genes was shut off. For such analysis H19 and Igf2 genes were activated by inducing differentiation of (mouse...
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