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Article

Superdominance among immunodominant H-2Kb-restricted epitopes and reversal by dendritic cell-mediated antigen delivery.

Journal of immunology (Baltimore, Md. : 1950) - 1 Apr 1998

Sandberg J K, Grufman P, Wolpert E Z, Franksson L, Chambers B J, Kärre K

Abstract excerpt

To examine possible interference patterns between immunodominant CTL Ags, we analyzed the response to mixtures of five well-characterized H-2Kb-restricted epitopes, each of which had earlier been described as immunodominant within its antigenic system. Clear patterns of dominance were observed between peptides in the mixture, with the CTL response focusing on the Sendai virus nucleoprotein 324-332 and vesicular...

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PMID: 9531271

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