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Article

The PNH phenotype cells that emerge in most patients after CAMPATH-1H therapy are present prior to treatment.

British journal of haematology - 1 Oct 1999

Rawstron A C, Rollinson S J, Richards S, Short M A, English A, Morgan G J, Hale G, Hillmen P

Abstract excerpt

Paroxysmal nocturnal haemoglobinuria (PNH) cells are deficient in glycosylphosphatidylinositol (GPI) linked antigens due to a somatic mutation of the PIG-A gene in a haemopoietic stem cell. It appears that a PNH clone reaches detectable proportions only when there is selection in its favour. GPI-deficient T lymphocytes have been identified in patients treated with CAMPATH-1H, a monoclonal antibody against the...

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Share to Antibodies, Monoclonal
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 10520035
DOI: 10.1046/j.1365-2141.1999.01676.x

Genes

GPI

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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