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Article

Paroxysmal nocturnal haemoglobinuria.

Nature reviews. Disease primers - 18 May 2017

Hill Anita, DeZern Amy E, Kinoshita Taroh, Brodsky Robert A

Abstract excerpt

Paroxysmal nocturnal haemoglobinuria (PNH) is a clonal haematopoietic stem cell (HSC) disease that presents with haemolytic anaemia, thrombosis and smooth muscle dystonias, as well as bone marrow failure in some cases. PNH is caused by somatic mutations in PIGA (which encodes phosphatidylinositol N-acetylglucosaminyltransferase subunit A) in one or more HSC clones. The gene product of PIGA is required for the...

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Share to Antibodies, Monoclonal, Humanized
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28516949
DOI: 10.1038/nrdp.2017.28
PMCID: PMC7879566

Genes

PIGA
GPI

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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