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Article

Impaired growth and fertility of cAMP-specific phosphodiesterase PDE4D-deficient mice.

Proceedings of the National Academy of Sciences of the United States of America - 12 Oct 1999

Jin S L, Richard F J, Kuo W P, D'Ercole A J, Conti M

Abstract excerpt

In eukaryotic cells, the inactivation of the cyclic nucleotide signal depends on a complex array of cyclic nucleotide phosphodiesterases (PDEs). Although it has been established that multiple PDE isoenzymes with distinct catalytic properties and regulations coexist in the same cell, the physiological significance of this remarkable complexity is poorly understood. To examine the role of a PDE in cAMP signaling in...

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Identifiers

PMID: 10518565
DOI: 10.1073/pnas.96.21.11998
PMCID: PMC18401

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

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