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Article

Critical role of phosphodiesterase 2A in mouse congenital heart defects.

Cardiovascular research - 1 May 2018

Assenza Maria Rita, Barbagallo Federica, Barrios Florencia, Cornacchione Marisa, Campolo Federica, Vivarelli Elisabetta, Gianfrilli Daniele, Auletta Luigi, Soricelli Andrea, Isidori Andrea M, Lenzi Andrea, Pellegrini Manuela, Naro Fabio

Abstract excerpt

Aims: Phosphodiesterase 2 A (Pde2A), a cAMP-hydrolysing enzyme, is essential for mouse development; however, the cause of Pde2A knockout embryonic lethality is unknown. To understand whether Pde2A plays a role in cardiac development, hearts of Pde2A deficient embryos were analysed at different stage of development. Methods and results: At the stage of four chambers, Pde2A deficient hearts were enlarged compared...

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PMID: 29409032
DOI: 10.1093/cvr/cvy030

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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