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Article

Cyclic nucleotide phosphodiesterases in <i>Drosophila melanogaster</i>

10 May 2005

Abstract excerpt

Cyclic nucleotide PDEs (phosphodiesterases) are important enzymes that regulate intracellular levels of cAMP and cGMP. In the present study, we identify and characterize novel PDEs in the genetic model, Drosophila melanogaster. The Drosophila genome encodes five novel PDE genes in addition to dunce. Predicted PDE sequences of Drosophila show highly conserved critical domains when compared with human PDEs. Thus...

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PMID: 15673286
DOI: 10.1042/bj20050057

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