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Article

Nuclear cGMP-dependent kinase regulates gene expression via activity-dependent recruitment of a conserved histone deacetylase complex.

PLoS genetics - 1 May 2011

Hao Yan, Xu Ningyi, Box Andrew C, Schaefer Laura, Kannan Kasthuri, Zhang Ying, Florens Laurence, Seidel Christopher, Washburn Michael P, Wiegraebe Winfried, Mak Ho Yi

Abstract excerpt

Elevation of the second messenger cGMP by nitric oxide (NO) activates the cGMP-dependent protein kinase PKG, which is key in regulating cardiovascular, intestinal, and neuronal functions in mammals. The NO-cGMP-PKG signaling pathway is also a major therapeutic target for cardiovascular and male reproductive diseases. Despite widespread effects of PKG activation, few molecular targets of PKG are known. We study...

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Identifiers

PMID: 21573134
DOI: 10.1371/journal.pgen.1002065
PMCID: PMC3088716

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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