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Article

Variants in nuclear factor I genes influence growth and development.

American journal of medical genetics. Part C, Seminars in medical genetics - 1 Dec 2019

Zenker Martin, Bunt Jens, Schanze Ina, Schanze Denny, Piper Michael, Priolo Manuela, Gerkes Erica H, Gronostajski Richard M, Richards Linda J, Vogt Julie, Wessels Marja W, Hennekam Raoul C

Abstract excerpt

The nuclear factor one (NFI) site-specific DNA-binding proteins represent a family of transcription factors that are important for the development of multiple organ systems, including the brain. During brain development in mice, the expression patterns of Nfia, Nfib, and Nfix overlap, and knockout mice for each of these exhibit overlapping brain defects, including megalencephaly, dysgenesis of the corpus...

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PMID: 31730271
DOI: 10.1002/ajmg.c.31747

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