Article
Compartmentalization of hepatitis C virus (HCV) during HCV/HIV coinfection.
The Journal of infectious diseases - 15 Jun 2007
Blackard Jason T, Hiasa Yoichi, Smeaton Laura, Jamieson Denise J, Rodriguez Irma, Mayer Kenneth H, Chung Raymond T
Abstract excerpt
Extrahepatic replication has important implications for the transmission and treatment of hepatitis C virus (HCV). We analyzed longitudinal HCV diversity in peripheral-blood mononuclear cells (PBMCs) and serum during HCV monoinfection and HCV/HIV coinfection to determine whether distinct amino acid signatures characterized HCV replicating within PBMCs. Analysis of E1-HVR1 sequences demonstrated higher serum...
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