Article
Cell-mediated graft rejection observed in two lines of human histocompatibility leukocyte antigen class I transgenic mice.
Transplantation - 27 Sept 1999
Ando Y, Beck Y, Tomikawa S, Eriguchi M, Muto T, Takiguchi M
Abstract excerpt
BACKGROUND: Human histocompatibility leukocyte antigen (HLA) class I molecules are essential for graft rejection. However, to determine the specific role of these molecules in clinical situations is difficult. We investigated the applicability of HLA class I transgenic mice (C3H.B35 and C3H.B51) for elucidation of the role of HLA class I molecules. METHODS: Skin or heart grafts were transplanted. Cytotoxic T...
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