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Article

The conversion gradient at HIS4 of Saccharomyces cerevisiae. I. Heteroduplex rejection and restoration of Mendelian segregation.

Genetics - 1 Oct 1999

Hillers K J, Stahl F W

Abstract excerpt

In Saccharomyces cerevisiae, some gene loci manifest gradients in the frequency of aberrant segregation in meiosis, with the high end of each gradient corresponding to a hotspot for DNA double-strand breaks (DSBs). The slope of a gradient is reduced when mismatch repair functions fail to act upon heteroduplex DNA-aberrant segregation frequencies at the low end of the gradient are higher in the absence of mismatch...

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Identifiers

PMID: 10511539
DOI: 10.1093/genetics/153.2.555
PMCID: PMC1460792

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