Article
The conversion gradient at HIS4 of Saccharomyces cerevisiae. I. Heteroduplex rejection and restoration of Mendelian segregation.
Genetics - 1 Oct 1999
Hillers K J, Stahl F W
Abstract excerpt
In Saccharomyces cerevisiae, some gene loci manifest gradients in the frequency of aberrant segregation in meiosis, with the high end of each gradient corresponding to a hotspot for DNA double-strand breaks (DSBs). The slope of a gradient is reduced when mismatch repair functions fail to act upon heteroduplex DNA-aberrant segregation frequencies at the low end of the gradient are higher in the absence of mismatch...
Topics
- Alcohol Oxidoreductases
- Alleles
- Aminohydrolases
- Crosses, Genetic
- DNA Repair
- DNA, Fungal
- Fungal Proteins
- Gene Conversion
- Models, Genetic
- Multienzyme Complexes
- Nucleic Acid Heteroduplexes
- Pyrophosphatases
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins
- Transcription Factors