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Article

Presenilin 1 suppresses the function of c-Jun homodimers via interaction with QM/Jif-1.

The Journal of cell biology - 4 Oct 1999

Imafuku I, Masaki T, Waragai M, Takeuchi S, Kawabata M, Hirai S, Ohno S, Nee L E, Lippa C F, Kanazawa I, Imagawa M, Okazawa H

Abstract excerpt

Presenilin 1 (PS1) is the causative gene for an autosomal dominant familial Alzheimer's disease (AD) mapped to chromosome 14. Here we show that QM/Jun-interacting factor (Jif)-1, a negative regulator of c-Jun, is a candidate to mediate the function of PS1 in the cell. We screened for proteins that bind to PS1 from a human embryonic brain cDNA library using the two-hybrid method and isolated one clone encoding the...

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Identifiers

PMID: 10508860
DOI: 10.1083/jcb.147.1.121
PMCID: PMC2164975

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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