c-Jun Transactivates the Promoter of the Human p21 Gene by Acting as a Superactivator of the Ubiquitous Transcription Factor Sp1

doi:10.1074/jbc.274.41.29572

Article

c-Jun Transactivates the Promoter of the Human p21 Gene by Acting as a Superactivator of the Ubiquitous Transcription Factor Sp1

1 Oct 1999

Abstract excerpt

The cell cycle inhibitor protein p21(WAF1/Cip1) (p21) is a critical downstream effector in p53-dependent mechanisms of growth control and p53-independent pathways of terminal differentiation. We have recently reported that the transforming growth factor-beta pathway-specific Smad3 and Smad4 proteins transactivate the human p21 promoter via a short proximal region, which contains multiple binding sites for the...

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.