Article
Conservation of FcepsilonRI gamma chain coding region in normals and in SLE patients.
Lupus - 1 Jan 2002
Wu J, Edberg J C, Gibson A W, Kimberly R P
Abstract excerpt
High-frequency single nucleotide polymorphism (SNP) alleles are useful in mapping genes responsible for disease susceptibility. Functionally, Fcgamma receptors (FcgammaR) have been implicated in autoimmune disease, and the gene encoding the signaling element for several FcgammaR, Fc-epsilon-receptor gamma-chain (FcepsilonRIgamma), has several SNPs in the immunoreceptor tyrosine activation motif (ITAM) recorded in...
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