An immunoglobulin switchlike sequence is linked with canine narcolepsy.

doi:10.1093/sleep/17.suppl_8.s68

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Article

An immunoglobulin switchlike sequence is linked with canine narcolepsy.

Sleep - 1 Dec 1994

Mignot E, Bell R A, Rattazzi C, Lovett M, Grumet F C, Dement W C

Abstract excerpt

Canine narcolepsy is an animal model of the human disorder that is transmitted as a single autosomal recessive gene with full penetrance (canarc-1) in Dobermans and Labradors. In previous experiments, we have identified a very tight linkage marker for canarc-1. This marker, a 0.85-kb band cross r...

Topics

Alleles
Animals
Cloning, Molecular
DNA
Dogs
Gene Deletion
Genetic Linkage
Genomic Library
Immunoglobulins
Narcolepsy
Pedigree
Polymorphism, Genetic

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