Article
An immunoglobulin switchlike sequence is linked with canine narcolepsy.
Sleep - 1 Dec 1994
Mignot E, Bell R A, Rattazzi C, Lovett M, Grumet F C, Dement W C
Abstract excerpt
Canine narcolepsy is an animal model of the human disorder that is transmitted as a single autosomal recessive gene with full penetrance (canarc-1) in Dobermans and Labradors. In previous experiments, we have identified a very tight linkage marker for canarc-1. This marker, a 0.85-kb band cross reacting with a human mu-switch Heavy-Chain Immunoglobulin probe (maximum logarithm of odds [LOD] score Zmax = 10.8 at...
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