Article
Analysis of an IFN-gamma gene (IFNG) polymorphism in multiple sclerosis in Europe: effect of population structure on association with disease.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research - 1 Sept 1999
Goris A, Epplen C, Fiten P, Andersson M, Murru R, Sciacca F L, Ronsse I, Jäckel S, Epplen J T, Marrosu M G, Olsson T, Grimaldi L M, Opdenakker G, Billiau A, Vandenbroeck K
Abstract excerpt
An intronic dinucleotide polymorphism in the IFN-gamma gene (IFNG) was used as a marker for testing association with multiple sclerosis (MS). Disease association was analyzed in case-control sets sampled from four geographically separate European populations (Germany, Northern Italy, Sardinia, and Sweden). Only in the Swedish was a weak disease association of the IFNG allele pattern found, mainly due to a higher...
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