Article
IFNG polymorphisms are associated with gender differences in susceptibility to multiple sclerosis.
Genes and immunity - 1 Mar 2005
Kantarci O H, Goris A, Hebrink D D, Heggarty S, Cunningham S, Alloza I, Atkinson E J, de Andrade M, McMurray C T, Graham C A, Hawkins S A, Billiau A, Dubois B, Weinshenker B G, Vandenbroeck K
Abstract excerpt
Interferon-gamma (IFNgamma) treatment is deleterious in multiple sclerosis (MS). MS occurs twice as frequently in women as in men. IFNgamma expression varies by gender. We studied a population-based sample of US MS patients and ethnicity-matched controls and independent Northern Irish and Belgian hospital-based patients and controls for association with MS, stratified by gender, of an intron 1 microsatellite...
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