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Article

Transforming growth factor-beta regulates tubular epithelial-myofibroblast transdifferentiation in vitro.

Kidney international - 1 Oct 1999

Fan J M, Ng Y Y, Hill P A, Nikolic-Paterson D J, Mu W, Atkins R C, Lan H Y

Abstract excerpt

BACKGROUND: We recently found evidence of tubular epithelial-myofibroblast transdifferentiation (TEMT) during the development of tubulointerstitial fibrosis in the rat remnant kidney. This study investigated the mechanisms that induce TEMT in vitro. METHODS: The normal rat kidney tubular epithelial cell line (NRK52E) was cultured for six days on plastic or collagen type I-coated plates in the presence or absence...

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PMID: 10504497
DOI: 10.1046/j.1523-1755.1999.00656.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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