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Article

Denaturing HPLC for mutation screening.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2011

Mitchell Mike, Cutler Jacqueline

Abstract excerpt

Denaturing High-Performance Liquid Chromatography (dHPLC) is probably the most versatile and one of the most widely used mutation screening technologies. It benefits from a combination of relative technical simplicity and a very high sensitivity (mutation detection rate), approaching 100%. DHPLC can reliably detect single-base mismatches in fragments between 150 and 500 bp, although detection in fragments up to...

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PMID: 20938830
DOI: 10.1007/978-1-60761-947-5_3

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