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Identification of specific BRCA1 and BRCA2 variants by DHPLC

26 Sept 2000

Abstract excerpt

Denaturing high performance liquid chromatography (DHPLC) is generating increasing interest in clinical genetics as a reliable tool for the analysis of genetic alterations. In the work presented here our intentions were to optimize primer design and DHPLC analysis conditions for a qualitative detection of BRCA1 and BRCA2 variations. The BRCA1 and BRAC2 genes display a high proportion of polymorphisms. Sequencing...

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PMID: 11013445
DOI: 10.1002/1098-1004(200010)16:4<345::aid-humu7>3.0.co;2-#

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