Article
DHPLC/SURVEYOR nuclease: a sensitive, rapid and affordable method to analyze BRCA1 and BRCA2 mutations in breast cancer families.
Molecular biotechnology - 1 Sept 2012
Pilato Brunella, De Summa Simona, Danza Katia, Papadimitriou Stavros, Zaccagna Paolo, Paradiso Angelo, Tommasi Stefania
Abstract excerpt
Hereditary breast cancer accounts for about 10% of all breast cancers and BRCA1 and BRCA2 genes have been identified as validated susceptibility genes for this pathology. Testing for BRCA gene mutations is usually based on a pre-screening approach, such as the partial denaturation DHPLC method, and capillary direct sequencing. However, this approach is time consuming due to the large size of BRCA1 and BRCA2...
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