Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Clonal analysis of neoplastic transformation in cultured diploid rat liver epithelial cells.

Basic life sciences - 1 Jan 1991

Grisham J W, Tsao M S, Lee L W, Smith G J

Abstract excerpt

Expression of TGF-alpha mRNA, which correlates well with the ability of cells to condition medium with an EGF-like activity, clonally segregates best with tumorigenicity among the several single phenotypes considered in this study. The results of unreported studies in which we have analyzed the quantitative relationships between the expression of selected phenotypes and tumorigenicity, suggest that the elevated...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Transformation, Neoplastic
Share to Clone Cells
Share to DNA, Neoplasm

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Neoplastic

Share to Phenotype

Source

Identifiers

PMID: 1814288
DOI: 10.1007/978-1-4684-5994-4_24

Genes

EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Clonal analysis of neoplastic transformation in cultured diploid rat liver epithelial cells.PMID 1814288Read ↗

Clonal analysis of the expression of multiple transformation phenotypes and tumorigenicity by morphologically transformed 10T1/2 cells.Semantic proximity Read ↗

Interactions between MYC and transforming growth factor alpha alter the growth and tumorigenicity of liver progenitor cells.Semantic proximity Read ↗

Relation of the slow growth phenotype to neoplastic transformation: possible significance for human cancer.Semantic proximity Read ↗

Transforming growth factor beta 1 promotes spontaneous transformation of cultured rat liver epithelial cells.Semantic proximity Read ↗

Characterization of liver epithelial cells transfected with myc and/or ras oncogenes.Semantic proximity Read ↗

Reduced Growth Capacity of Hepatocytes from c-myc and c-myc/TGF-α Transgenic Mice in Primary CultureSemantic proximity Read ↗

Minimal cooperation between mutant Hras and c-myc or TGFα in the regulation of mouse hepatocyte growth or transformation in vivo.Semantic proximity Read ↗

Spontaneous neoplastic transformation of WB-F344 rat liver epithelial cells.Semantic proximity Read ↗

Growth characteristics and Ha-ras mutations of cell cultures isolated from chemically induced mouse liver tumours.Semantic proximity Read ↗

The effects of continuous exposure to epidermal growth factor on the spontaneous transformation of cultured rat liver epithelial cells.Semantic proximity Read ↗

Quantitation of Multistage Carcinogenesis in Rat LiverSemantic proximity Read ↗

Molecular analyses of liver tumors in c-myc transgenic mice and c-myc and TGF-alpha double transgenic mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.