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Article

Gradual phenotypic conversion associated with immortalization of cultured human mammary epithelial cells.

Molecular biology of the cell - 1 Dec 1997

Stampfer M R, Bodnar A, Garbe J, Wong M, Pan A, Villeponteau B, Yaswen P

Abstract excerpt

Examination of the process of immortal transformation in early passages of two human mammary epithelial cell (HMEC) lines suggests the involvement of an epigenetic step. These lines, 184A1 and 184B5, arose after in vitro exposure of finite lifespan 184 HMEC to a chemical carcinogen, and both are clonally derived. Although early-passage mass cultures of 184A1 and 184B5 maintained continuous slow growth, most...

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Identifiers

PMID: 9398663
DOI: 10.1091/mbc.8.12.2391
PMCID: PMC25715

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Source receipt: pubmed, retrieved 7 Sept 2026.

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