Article
Gradual phenotypic conversion associated with immortalization of cultured human mammary epithelial cells.
Molecular biology of the cell - 1 Dec 1997
Stampfer M R, Bodnar A, Garbe J, Wong M, Pan A, Villeponteau B, Yaswen P
Abstract excerpt
Examination of the process of immortal transformation in early passages of two human mammary epithelial cell (HMEC) lines suggests the involvement of an epigenetic step. These lines, 184A1 and 184B5, arose after in vitro exposure of finite lifespan 184 HMEC to a chemical carcinogen, and both are...
Topics
- Adult
- Breast
- Carcinogens
- Cell Division
- Cell Line, Transformed
- Cell Size
- Cells, Cultured
- Cellular Senescence
- Epithelial Cells
- Female
- Humans
- Phenotype
- Telomerase
- Telomere
- Time Factors
- Transforming Growth Factor beta