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Article

Cyclin D1 Antagonizes BRCA1 Repression of Estrogen Receptor α Activity

1 Aug 2005

Abstract excerpt

The cyclin D1 gene is frequently overexpressed in human breast cancer and is capable of inducing mammary tumorigenesis when overexpressed in transgenic mice. The BRCA1 breast tumor susceptibility gene product inhibits breast cancer cellular growth and the activity of several transcription factors. Herein, cyclin D1 antagonized BRCA1-mediated repression of estrogen receptor alpha (ERalpha)-dependent gene...

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PMID: 16061635
DOI: 10.1158/0008-5472.can-05-0486

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