Article
Pitx2 participates in the late phase of the pathway controlling left-right asymmetry.
Cell - 7 Aug 1998
Piedra M E, Icardo J M, Albajar M, Rodriguez-Rey J C, Ros M A
Abstract excerpt
Pitx2, a member of the bicoid-related family of homeobox-containing genes, is asymmetrically expressed in the left lateral plate mesoderm and derived tissues during chick and mouse development. Modifications of Pitx2 pattern of expression in the iv mouse mutation correlate with the situs alterati...
Topics
- Animals
- Body Patterning
- Chick Embryo
- Conserved Sequence
- Gene Expression Regulation, Developmental
- Homeodomain Proteins
- Mesoderm
- Mice
- Mice, Inbred C57BL
- Mice, Mutant Strains
- Mutation
- Nodal Protein
- Nuclear Proteins
- Paired Box Transcription Factors
- Proteins
- Signal Transduction
- Situs Inversus
- Transcription Factors