Article
Endothelin B receptor modulates inflammatory pain and cutaneous inflammation.
Molecular pharmacology - 1 Oct 1999
Griswold D E, Douglas S A, Martin L D, Davis T G, Davis L, Ao Z, Luttmann M A, Pullen M, Nambi P, Hay D W, Ohlstein E H
Abstract excerpt
The role of endothelin B (ET(B)) receptors in inflammation and nociception was examined using ET(B) receptor knockout mice. Genotyping studies were used with tissues from ET(B)((+/+)), ET(B)((+/-)), and ET(B)((-/-)) mice to confirm the loss of ET(B) receptors. Algesia induced by phenylbenzoquinone was evident in the (+/+) mice, reduced by approximately 80% in the (+/-) mice, and absent in the (-/-) mice....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.