Article
Oral immunization using live attenuated Salmonella spp. as carriers of foreign antigens.
Clinical microbiology reviews - 1 Jul 1992
Cárdenas L, Clements J D
Abstract excerpt
A variety of techniques, including the use of live oral vaccines, have been used to deliver antigens to the gut-associated lymphoid tissues in an attempt to initiate production of specific secretory immunoglobulin A for protection against pathogens that colonize or cross mucosal surfaces to initiate infection. A number of attenuated Salmonella mutants are able to interact with the lymphoid tissues in the Peyer's...
Topics
- Administration, Oral
- Antigens
- Bacterial Vaccines
- Genetic Vectors
- Humans
- Immunization
- Mutation
- Salmonella
- Vaccines, Attenuated