Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Tuning the human heart molecular motors by myosin light chains.

Journal of molecular medicine (Berlin, Germany) - 1 Jul 1999

Morano I

Abstract excerpt

Cardiac contraction is triggered by the cyclic interaction of the "molecular motor" protein myosin with the actin filament, consuming ATP as the energy source to produce tension or shortening. The myosin heavy chain (MHC) contains the actin- and ATP-binding sites and represents the molecular motor of muscle contraction. This review describes the various subunits of human heart myosin in health and disease and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Actins
Share to Cardiac Myosins
Share to Heart

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Myocardial Contraction

Share to Myocardium

Share to Myosin Heavy Chains

Share to Myosin Light Chains

Share to Protein Isoforms

Source

Identifiers

PMID: 10494800
DOI: 10.1007/s001099900031

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Tuning the human heart molecular motors by myosin light chains.PMID 10494800Read ↗

The mammalian myosin heavy chain gene family.Semantic proximity Read ↗

Biophysical properties of human β-cardiac myosin with converter mutations that cause hypertrophic cardiomyopathySemantic proximity Read ↗

Heavy and light roles: myosin in the morphogenesis of the heartSemantic proximity Read ↗

Molecular mechanisms of cardiomyopathy phenotypes associated with myosin light chain mutations.Semantic proximity Read ↗

Biophysical properties of human β-cardiac myosin with converter mutations that cause hypertrophic cardiomyopathySemantic proximity Read ↗

[Cardiac contractile proteins].Semantic proximity Read ↗

Regulatory light chain mutations associated with cardiomyopathy affect myosin mechanics and kinetics.Semantic proximity Read ↗

Early-Onset Hypertrophic Cardiomyopathy Mutations Significantly Increase the Velocity, Force, and Actin-Activated ATPase Activity of Human β-Cardiac Myosin.Semantic proximity Read ↗

The hypertrophic cardiomyopathy mutation G768R makes cardiac myosin a high duty ratio motorSemantic proximity Read ↗

The ATPase cycle of Human Muscle Myosin II Isoforms: Adaptation of a single mechanochemical cycle for different physiological rolesSemantic proximity Read ↗

Mutations in the catalytic domain of human β-cardiac myosin that cause early onset hypertrophic cardiomyopathy significantly increase the fundamental parameters that determine ensemble force and velocitySemantic proximity Read ↗

The Myosin Family of Mechanoenzymes: From Mechanisms to Therapeutic Approaches.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.