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Article

The Myosin Family of Mechanoenzymes: From Mechanisms to Therapeutic Approaches.

Annual review of biochemistry - 20 Jun 2020

Trivedi Darshan V, Nag Suman, Spudich Annamma, Ruppel Kathleen M, Spudich James A

Abstract excerpt

Myosins are among the most fascinating enzymes in biology. As extremely allosteric chemomechanical molecular machines, myosins are involved in myriad pivotal cellular functions and are frequently sites of mutations leading to disease phenotypes. Human β-cardiac myosin has proved to be an excellent target for small-molecule therapeutics for heart muscle diseases, and, as we describe here, other myosin family...

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Identifiers

PMID: 32169021
DOI: 10.1146/annurev-biochem-011520-105234
PMCID: PMC8742983

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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