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Hereditary homozygous heparin cofactor II deficiency and the risk of developing venous thrombosis.

Thrombosis and haemostasis - 1 Sept 1999

Villa P, Aznar J, Vaya A, España F, Ferrando F, Mira Y, Estellés A

Abstract excerpt

Heparin cofactor II (HCII) is a specific inhibitor of thrombin in the presence of heparin or dermatan sulphate. Although there have been reports on families in which a heterozygous HCII deficiency is associated with thromboembolic events, several epidemiological studies revealed that heterozygous HCII deficiency is as prevalent among healthy subjects as it is among patients with deep venous thrombosis (DVT). It...

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PMID: 10494755

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