Article
Homozygous deficiency of heparin cofactor II: relevance of P17 glutamate residue in serpins, relationship with conformational diseases, and role in thrombosis.
Circulation - 7 Sept 2004
Corral Javier, Aznar Justo, Gonzalez-Conejero Rocio, Villa Piedad, Miñano Antonia, Vayá Amparo, Carrell Robin W, Huntington James A, Vicente Vicente
Abstract excerpt
BACKGROUND: Heparin cofactor II (HCII) is a hepatic serpin with significant antithrombin activity that has been implicated in coagulation, inflammation, atherosclerosis, and wound repair. Recent data obtained in mice lacking HCII suggest that this serpin might inhibit thrombosis in the arterial circulation. However, the clinical relevance and molecular mechanisms associated with deficiency of HCII in humans are...
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