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Article

Critical role of the transcriptional repressor neuron-restrictive silencer factor in the specific control of connexin36 in insulin-producing cell lines.

The Journal of biological chemistry - 26 Dec 2003

Martin David, Tawadros Thomas, Meylan Laure, Abderrahmani Amar, Condorelli Daniele F, Waeber Gérard, Haefliger Jacques-Antoine

Abstract excerpt

Connexin36 (Cx36) is specifically expressed in neurons and in pancreatic beta-cells. Cx36 functions as a critical regulator of insulin secretion and content in beta-cells. In order to identify the molecular mechanisms that control the beta-cell expression of Cx36, we initiated the characterizatio...

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Identifiers

PMID: 14565956
DOI: 10.1074/jbc.M306861200

Genes

REST
INS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-14565956-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Critical role of the transcriptional repressor neuron-restrictive silencer factor in the specific control of connexin36 in insulin-producing cell lines.PMID 14565956Read ↗

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Repressor element-1 silencing transcription/neuron-restrictive silencer factor is required for neural sodium channel expression during development of Xenopus.Semantic proximity Read ↗

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Regulation of human tyrosine hydroxylase gene by neuron-restrictive silencer factor.Semantic proximity Read ↗

The neuron-restrictive silencer element-neuron-restrictive silencer factor system regulates basal and endothelin 1-inducible atrial natriuretic peptide gene expression in ventricular myocytes.Semantic proximity Read ↗

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