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Article

Stathmin: a protein with many tasks. New biomarker and potential target in cancer

7 Oct 2011

Abstract excerpt

INTRODUCTION: Stathmin is a microtubule-destabilizing phosphoprotein, firstly identified as the downstream target of many signal transduction pathways. Several studies then indicated that stathmin is overexpressed in many types of human malignancies, thus deserving the name of Oncoprotein 18 (Op18). At molecular level, stathmin depolymerizes microtubules by either sequestering free tubulin dimers or directly...

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PMID: 21978024
DOI: 10.1517/14728222.2011.620951

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