Article
Tyrosine hydroxylase polymorphism and phenotypic heterogeneity in bipolar affective disorder: a multicenter association study.
American journal of medical genetics - 15 Oct 1999
Souery D, Lipp O, Rivelli S K, Massat I, Serretti A, Cavallini C, Ackenheil M, Adolfsson R, Aschauer H, Blackwood D, Dam H, Dikeos D, Fuchshuber S, Heiden M, Jakovljevic M, Kaneva R, Kessing L, Lerer B, Lönnqvist J, Mellerup T, Milanova V, Muir W, Nylander P O, Oruc L, Mendlewicz J
Abstract excerpt
Tyrosine hydroxylase (TH), the rate-limiting enzyme in the metabolism of catecholamines, is considered a candidate gene in bipolar affective disorder (BPAD) and has been the subject of numerous linkage and association studies. Taken together, most results do not support a major gene effect for the TH gene in BPAD. Genetic and phenotypic heterogeneity may partially explain the difficulty of confirming the exact...
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