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Article

Analysis and metaanalysis of two polymorphisms within the tyrosine hydroxylase gene in bipolar and unipolar affective disorders

5 Feb 1999

Abstract excerpt

Tyrosine hydroxylase (TH) is the rate-limiting enzyme in the synthesis of dopamine and noradrenaline. While positive associations between TH and bipolar affective disorder have been found in several studies, many studies have failed to reproduce these results. In order to clarify this situation, association studies of bipolar and unipolar affective disorder groups and metaanalyses of published data on the TH...

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PMID: 10050974
DOI: 10.1002/(sici)1096-8628(19990205)88:1<88::aid-ajmg16>3.0.co;2-j

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