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Association and haplotype analysis at the tyrosine hydroxylase locus in a combined German-British sample of manic depressive patients and controls.

Psychiatric genetics - 1 Jan 1994

Körner J, Rietschel M, Hunt N, Castle D, Gill M, Nöthen M M, Craddock N, Daniels J, Owen M, Fimmers R

Abstract excerpt

Tyrosine hydroxylase (TH) is the key enzyme in the synthesis of catecholamines and may therefore be of aetiological relevance in the development of psychiatric illness. Hipolar affective disorder association studies, with restriction fragment length polymorphisms located in flanking regions of the TH gene, have shown conflicting results. Alleles of a tetranucleotide repeat polymorphism (TH4) located in intron 1...

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PMID: 7719703
DOI: 10.1097/00041444-199400430-00007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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