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Article

High throughput fluorescent CE-SSCP SNP genotyping.

Molecular psychiatry - 1 Jul 1999

Gonen D, Veenstra-VanderWeele J, Yang Z, Leventhal B, Cook E H

Abstract excerpt

Large numbers of single nucleotide polymorphisms (SNPs) are being identified by several laboratories for the purpose of developing dense genetic maps. Single-strand conformation polymorphism (SSCP) analysis has been widely used as a method for detecting novel sequence variations in PCR products. Differences in migration of single-stranded DNA can be used not only to find mutations, but to genotype SNPs in large...

Topics

Automation
Chromosome Mapping
DNA Primers
Electrophoresis, Capillary
Fluorescent Dyes
Genotype
Humans
Point Mutation
Polymerase Chain Reaction
Polymorphism, Genetic
Polymorphism, Single-Stranded Conformational

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 10483050
DOI: 10.1038/sj.mp.4000564

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