Article
Requirement of cysteines and length of the human respiratory syncytial virus M2-1 protein for protein function and virus viability.
Journal of virology - 1 Dec 2001
Tang R S, Nguyen N, Cheng X, Jin H
Abstract excerpt
The M2-1 protein of human respiratory syncytial virus (hRSV) promotes processive RNA synthesis and readthrough at RSV gene junctions. It contains four highly conserved cysteines, three of which are located in the Cys(3)-His(1) motif at the N terminus of M2-1. Each of the four cysteines, at positions 7, 15, 21, and 96, in the M2-1 protein of hRSV A2 strain was individually replaced by glycines. When tested in an...
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