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Article

Adaptation to promiscuous usage of chemokine receptors is not a prerequisite for human immunodeficiency virus type 1 disease progression.

The Journal of infectious diseases - 1 Oct 1999

de Roda Husman A M, van Rij R P, Blaak H, Broersen S, Schuitemaker H

Abstract excerpt

Fifty percent of individuals infected with human immunodeficiency virus type 1 (HIV-1) progress to AIDS in the presence of only non-syncytium-inducing (NSI) variants. These rapidly replicating NSI isolates are associated with a high viral load. The question of whether disease progression in the absence of syncytium-inducing (SI) HIV-1 variants is associated with an expansion of the coreceptor repertoire of NSI...

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Source

Identifiers

PMID: 10479137
DOI: 10.1086/314987

Genes

CCR5
CCR1
CCR3
CXCR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Adaptation to promiscuous usage of chemokine receptors is not a prerequisite for human immunodeficiency virus type 1 disease progression.PMID 10479137Read ↗

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Adaptation to promiscuous usage of CC and CXC-chemokine coreceptors in vivo correlates with HIV-1 disease progressionSemantic proximity Read ↗

Change in Coreceptor Use Correlates with Disease Progression in HIV-1–Infected IndividualsSemantic proximity Read ↗

Coreceptor Usage of Human Immunodeficiency Virus Type 2 Primary Isolates and Biological Clones Is Broad and Does Not Correlate with Their Syncytium-Inducing CapacitiesSemantic proximity Read ↗

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Chemokine coreceptor usage by diverse primary isolates of human immunodeficiency virus type 1.Semantic proximity Read ↗

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Evolution of the Human Immunodeficiency Virus Type 1 Envelope during Infection Reveals Molecular Corollaries of Specificity for Coreceptor Utilization and AIDS PathogenesisSemantic proximity Read ↗

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