Article
The catecholamines up (Catsup) protein of Drosophila melanogaster functions as a negative regulator of tyrosine hydroxylase activity.
Genetics - 1 Sept 1999
Stathakis D G, Burton D Y, McIvor W E, Krishnakumar S, Wright T R, O'Donnell J M
Abstract excerpt
We report the genetic, phenotypic, and biochemical analyses of Catecholamines up (Catsup), a gene that encodes a negative regulator of tyrosine hydroxylase (TH) activity. Mutations within this locus are semidominant lethals of variable penetrance that result in three broad, overlapping effective lethal phases (ELPs), indicating that the Catsup gene product is essential throughout development. Mutants from each...
Topics
- Animals
- Catecholamines
- Dopamine
- Drosophila melanogaster
- Enzyme Activation
- Female
- Fertility
- Genes, Dominant
- Genes, Insect
- Genes, Lethal
- Genotype
- Insect Proteins
- Male
- Melanins