The mec-8 gene of Caenorhabditis elegans affects muscle and sensory neuron function and interacts with three other genes: unc-52, smu-1 and smu-2.

doi:10.1093/genetics/138.1.83

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Article

The mec-8 gene of Caenorhabditis elegans affects muscle and sensory neuron function and interacts with three other genes: unc-52, smu-1 and smu-2.

Genetics - 1 Sept 1994

Lundquist E A, Herman R K

Abstract excerpt

Mutations in the Caenorhabditis elegans gene mec-8 were previously shown to cause defects in mechanosensation and in the structure and dye filling of certain chemosensory neurons. Using noncomplementation screens, we have identified eight new mec-8 alleles and a deficiency that uncovers the locus. Strong mec-8 mutants exhibit an incompletely penetrant cold-sensitive embryonic and larval arrest, which we have...

Topics

Alleles
Animals
Caenorhabditis elegans
Caenorhabditis elegans Proteins
Chromosome Mapping
Female
Genes, Helminth
Genes, Lethal
Helminth Proteins
Male
Membrane Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Muscles

Mutation

Neurons, Afferent

Phenotype

Proteoglycans

Suppression, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 8001796
DOI: 10.1093/genetics/138.1.83
PMCID: PMC1206141

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8001796-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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The mec-8 gene of Caenorhabditis elegans affects muscle and sensory neuron function and interacts with three other genes: unc-52, smu-1 and smu-2.PMID 8001796Read ↗

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