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Article

Bone extracellular matrix stimulates invasiveness of estrogen-responsive human mammary MCF-7 cells.

International journal of cancer - 8 Oct 1999

Martínez J, Fuentes M, Cambiazo V, Santibáñez J F

Abstract excerpt

Bone is the most frequent site of metastasis in breast cancer. This causes destructive osteolytic lesions. To achieve metastasis to bone, breast cancer cells must proliferate in a new microenvironment, arrest on extracellular matrix and invade. Breast cancer cells progress in the invasive processes only if they destroy bone with the assistance of osteoclasts. In this work, we present data suggesting that MCF-7...

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Source

Identifiers

PMID: 10471539
DOI: 10.1002/(sici)1097-0215(19991008)83:2<278::aid-ijc21>3.0.co;2-7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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