Article
IL-1β produced by aggressive breast cancer cells is one of the factors that dictate their interactions with mesenchymal stem cells through chemokine production.
Oncotarget - 6 Oct 2015
Escobar Pauline, Bouclier Céline, Serret Julien, Bièche Ivan, Brigitte Madly, Caicedo Andres, Sanchez Elodie, Vacher Sophie, Vignais Marie-Luce, Bourin Philippe, Geneviève David, Molina Franck, Jorgensen Christian, Lazennec Gwendal
Abstract excerpt
The aim of this work was to understand whether the nature of breast cancer cells could modify the nature of the dialog of mesenchymal stem cells (MSCs) with cancer cells. By treating MSCs with the conditioned medium of metastatic Estrogen-receptor (ER)-negative MDA-MB-231, or non-metastatic ER-positive MCF-7 breast cancer cells, we observed that a number of chemokines were produced at higher levels by MSCs...
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