Article
Stimulators of mineralization limit the invasive phenotype of human osteosarcoma cells by a mechanism involving impaired invadopodia formation.
PloS one - 1 Jan 2014
Cmoch Anna, Podszywalow-Bartnicka Paulina, Palczewska Malgorzata, Piwocka Katarzyna, Groves Patrick, Pikula Slawomir
Abstract excerpt
BACKGROUND: Osteosarcoma (OS) is a highly aggressive bone cancer affecting children and young adults. Growing evidence connects the invasive potential of OS cells with their ability to form invadopodia (structures specialized in extracellular matrix proteolysis). RESULTS: In this study, we tested...
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